Organon and MRC Technology sign antibody development agreement

The collaborative agreement will cover development of a humanised antibody for the treatment of certain forms of cancer. The Therapeutic Antibody Group (TAG) at MRCT will use its proprietary CDR grafting technology to generate a humanised clinical candidate from a murine antibody discovered at Organon’s Research Center in Cambridge, MA,.

MRCT to humanize antibody to treat SLE

SLE is a very important disease area, affecting over 1.5 Million people in the USA without any effective therapies. MRCT will use its proprietary humanization technology to generate the humanized clinical candidate from Ginkgo Biomedical Research Institute's mouse antibody.

MRCT to humanize antibody to treat AD

MRC Technologyand BioArctic Neuroscience have signed an collaborative research agreement to humanise a mouse antibody under development with BioArctic for the treatment of Alzheimer’s disease. The Therapeutic Antibody Group (TAG) at MRCT will use its proprietary humanisation technology to generate the humanised clinical candidate.

Domantis wins award

Domantis, a spin-out company from the MRC, is the first to win the UK Innovation in Drug…

TYSABRI gains market approval

Biogen Idec and Elan Corporation yesterday announced the approval of a supplemental Biologics License Application (sBLA) by the U.S. Food and Drug Administration (FDA) for the reintroduction of TYSABRI® (natalizumab) as a monotherapy treatment for relapsing forms of multiple sclerosis (MS) to slow the progression of disability and reduce the frequency of clinical relapses.

MRCT and Chinese National Centre collaborate on malaria

MRCT's Drug Discovery Group has developed a drug screening assay for a potential Malaria drug target called PfSub-1, a subtilisin-like protease, and successfully identified a small number of ‘hit’ compounds from its own in house chemical library. The collaboration with NCDS will allow the target to be screened against a much larger compound library. Apart from synthetic chemicals, the NCDS library also contains a large collection of compounds isolated from natural products including traditional Chinese herbs.

Therapeutic Antibody Group starts

The Therapeutic Antibody Group (TAG) will comprise former AERES scientists. As part of MRCT’s evolving strategy of adding significant value to key MRC intellectual property assets, TAG will collaborate with MRC scientists to translate innovative drug targets into potent and selective therapeutic antibody candidates which can then be partnered with industry for progression into pre-clinical and clinical studies.

MRC to receive over USD200m

The Medical Research Council is to receive over US$200m as part of one of the biggest deals to come out of breakthroughs by British scientists. It involves a drug created using patented technology derived from research at the MRC Laboratory of Molecular Biology in Cambridge and The Scripps Research Institute in California.