Translational Challenges
We focus on work where our translational knowledge can help people living with rare conditions and tackle some of the major infection-related threats facing human health.
Each Translational Challenge targets a specific area or disease where research has great potential to deliver impact but lacks the translational infrastructure needed to bring discoveries to patients.
We bring our science, expertise and funding to these challenges, working with charities and people affected by these conditions to help guide us. We also work closely with partners to tap into their expertise and capabilities.
Our Translational Challenges
Motor Neuron Disease
Our vision is a world where motor neuron disease is preventable and treatable.
Chronic & Rare Respiratory Disease
Our vision is improved quality of life for those living with cystic fibrosis and bronchiectasis.
Global Health
Improving solutions for treating and preventing infectious diseases through 3 Translational Challenges: Antimicrobial Resistance, Neglected Tropical Diseases and Emerging Viral Threats.
Rare Disease
Our vision is an ecosystem working together to get discoveries and treatments to rare disease patients faster.
Childhood Cancer
Our vision is to drive life-changing innovations for children with cancer through collaborating with partners to tackle the unique challenges of research in this space.
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Latest news
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First‑of‑its‑kind UK data initiative to boost early diagnosis and deliver better treatments for children with rare diseases
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The future of brain health: Early detection, equity and systematic change
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Could a nasal insulin spray improve the lives of children and young people living with a rare condition?