MRC licensing opportunities – research tools and reagents

The Medical Research Council (MRC) aims to make the valuable research tools and reagents generated by MRC scientists accessible to the wider scientific community. LifeArc manages these on behalf of the MRC for academic research use and commercial licensing.

For academic research, we can help get a standard Material Transfer Agreement (MTA) in place. For commercial purposes, materials are licensed on a non-exclusive basis for sale as catalogue reagents, in-house R&D purposes, and other commercial applications. Once a license or MTA is in place, materials will be released from our partner repositories or academics labs.

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Type

  • YB2/0

    Submit Enquiry: YB2/0
    Track code: A857/249
    Species: Rat
    Cell type: Myeloma
    Uses: Fusion partner for hybridomas; protein expression
    Growth medium: DMEM + FBS

    Description:

    The YB2/0 cell line was produced by fusing Y3/Ag1.2.3 cells with spleen cells from an AO strain rat. It is a non-Ig secreting, non-light chain-synthesising clone and can be used as a fusion partner for rat B cells to make rat -rat hybridomas to produce antibodies. It has successfully been used to produce several approved biologic therapeutics.

  • NS0-Turbodoma

    Submit Enquiry: NS0-Turbodoma
    Track code: C-0532
    Species: Mouse
    Cell type: Myeloma
    Uses: Fusion partner for hybridomas; protein expression
    Growth medium: Turbodoma media

    Description:

    NS0 cell line adapted to grow in the chemically defined protein- and peptide-free medium Turbodoma (Cell Culture Technologies). This version of NS0 can be used in research and commercial production of therapeutic biologics and other proteins, including as a fusion parent for serum-free generation of hybridomas to produce antibodies.

  • NS0-Serum-Free

    Submit Enquiry: NS0-Serum-Free
    Track code: C-0531
    Species: Mouse
    Cell type: Myeloma
    Uses: Fusion partner for hybridomas; protein expression
    Growth medium: Serum-free media

    Description:

    NS0 cell line adapted to grow in the serum-free medium EX-CELL® NS0 Serum-Free Medium for NS0 Cells (Sigma 14650C). This version of NS0 can be used in research and commercial production of therapeutic biologics and other proteins, including as a fusion parent for serum-free generation of hybridomas to produce antibodies.

  • NS0

    Submit Enquiry: NS0
    Track code: A857/213
    Species: Mouse
    Cell type: Myeloma
    Uses: Fusion partner for hybridomas; protein expression
    Growth medium: RPMI + FBS

    Description:

    NS0 is a cell line derived from murine myeloma. It is a non-Ig secreting, non-light chain-synthesising subclone of NS-1 (P3/NS1/1-Ag4-1). NS0 can be used in research and commercial production of therapeutic biologics and other proteins, including as a fusion parent for generation of hybridomas to produce antibodies. It has successfully been used to produce several approved biologic therapeutics.

  • hTau: p301s mouse model

    Submit Enquiry: hTau: p301s mouse model
    Track code: A857/3004
    Species: Mouse
    Background: CBA x C57BL6
    Modification Type: Knock-in – Thy1 promoter
    Modification: Expresses human 0N4R Tau-P301S
    Disease Modelled: Neurodegeneration
    Strain Designation: N/A

    Description:

    The P301S mutation causes a dominantly inherited tauopathy in humans. The transgenic mouse model recapitulates many hallmarks of tauopathy, including tau hyperphosphorylation, tau filament formation and neurodegeneration in brain and spinal cord.