hTau: p301s mouse model

hTau: p301s mouse model

Track code: A857/3004
Species: Mouse
Background: CBA x C57BL6
Modification Type: Knock-in – Thy1 promoter
Modification: Expresses human 0N4R Tau-P301S
Disease Modelled: Neurodegeneration
Strain Designation: N/A

Description:

The P301S mutation causes a dominantly inherited tauopathy in humans. The transgenic mouse model recapitulates many hallmarks of tauopathy, including tau hyperphosphorylation, tau filament formation and neurodegeneration in brain and spinal cord.