TASK-2 Activators

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TASK-2 Activators

Early Discovery

Lead Generation

Lead Optimisation

Preclinical Development

Modality

Small molecules

Therapeutic area

Neuroscience

Advantages

Despite important roles in pathophysiology, K2Ps have proven a difficult target class to modulate with small molecules. LifeArc has developed and successfully deployed a novel system to identify small molecule K2P activators, and have strategic relationships in place to deliver high quality drug discovery in the K2P space.

Background info

Two pore domain potassium channels (K2Ps) have been implicated in a number of human diseases including Pain and Migraine. A number of K2Ps show genetic linkage (e.g. Migraine for TASK2 and TRESK). LifeArc has active chemistry programs for TASK-2 with potent and efficacious activators identified.

Indication

Pain and Migraine

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