Small molecule drug discovery
Increase your drug’s likelihood of progressing through development to the clinic.
Collaborate with us to access our state-of-the-art research facilities in Stevenage, gain valuable support from our highly experienced scientists, and leverage our longstanding drug discovery expertise in small molecules and biologics.
We can also offer personalised strategic advice on potential development routes to market and facilitate connections with commercial partners.
Our track record
30 years’
experience in drug discovery
Humanised antibodies for
5 licenced medicines
Our capabilities
We use our compound libraries, external libraries and structure-guided discovery to support the development of new small molecule drugs.
Targeted protein degradation
We’re building our capacity here, with a focus on PROTACs and E3 ligases to degrade target proteins that aren’t classically targetable by small molecule inhibitors.
Assay development
We develop assays to support target validation, drug discovery, and compound characterisation, ensuring robust and translatable data throughout the discovery process.
Structural biology / in silico screening
Our structure-based drug design capability is supported by advanced techniques such as machine learning to improve drug design and compound optimisation.
Medicinal chemistry
We design and optimise small molecules using industry-standard workflows, supported by computational chemistry and advanced data visualisation tools.
We also support antibody development through our antibody humanization and discovery capabilities.
We are looking for research projects related to our Translational Challenges that demonstrate:
- Novel therapeutic targets
- New approaches to modulating a known disease target
- Strong evidence linking the target to human disease
- Evidence from model systems showing that modulation of the target has a therapeutically relevant effect
- Disease biology expertise, such as access to enabling assays, reagents and disease models
- New technologies that could speed up drug discovery or allow us to tackle diseases and targets that can’t currently be treated
Who to contact
-
Volker Germaschewski
Read bio: Volker Germaschewski
Other ways we can support you
Clinical trial support
We can help you progress healthcare innovations through clinical trials and into clinical use.
Antibody development
Access to our advanced antibody technologies, support from our experienced scientists, and over 30 years of antibody expertise.
Diagnostics development
We support all stages of diagnostics development, from assay design through to clinical validation
Contact us
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