Strategy and Insights

Motor Neuron Disease and Rare Dementias

MND insights report on future treatment priorities

This report, from our MND Insights Group, contains the findings from workshops and a community-wide survey.

MND biomarker roadmap report

We hosted a roundtable with MND biomarker experts to tackle key challenges and explore solutions. This report shares insights to advance the field.

Unmet needs and opportunities in MND biomarker cover image

MND insights report on how technology could help with daily challenges

These perspectives are now being used to inform funding calls, programmes and research design, ensuring scientific progress reflects what truly matters to people with MND and their families.

A review of best practices in Motor Neuron Disease drug discovery

Applicants were asked to refer to this review, published alongside our funding call, which outlines principles for improving preclinical research and de-risking MND clinical trials.

Cover image for Guiding principles for drug discovery report

Chronic and Rare Respiratory

Transforming respiratory health report

This report captures insights from a 2023 workshop hosted by LifeArc and Asthma+Lung UK, bringing together experts and people with lived experience to explore the future of respiratory diagnostics.

Transforming respiratory diagnostics: A simple lung test TPP

People with lung conditions helped define priorities for a Target Product Profile (TPP) to guide the creation of simple lung tests that can speed up diagnosis of chronic and rare respiratory conditions in primary care.

Bronchiectasis industry factsheet

Bronchiectasis affects 1 in 200 adults in the UK, yet remains widely overlooked. This factsheet outlines the challenges driving underdiagnosis and limited research, while spotlighting the significant opportunity to improve awareness, treatment, and outcomes.

Rare Disease

Accelerating R&D for rare disease in the UK

This rare disease taskforce report, developed with Genetic Alliance UK and our Rare Disease Taskforce, gives recommendations to streamline the UK R&D landscape to accelerate diagnoses and access to treatments.

More trials, better data, faster access

The Translational Centres for Rare Disease Hub’s Policy Working Group developed this report to highlight where policy can have the greatest impact in unlocking innovation for rare conditions.

Drug repurposing report

This report explores the potential of drug repurposing as a faster, more cost-effective route to delivering new treatments for both common and rare diseases.

Childhood Cancer

Addressing unmet needs in childhood cancer

This report shares insights from a consultation with the childhood cancer community, identifying the greatest unmet needs and opportunities for progress

Science and Data

Antibody discovery and humanisation

This booklet introduces our antibody discovery and humanisation capabilities, supporting the development of high-quality therapeutic antibodies.

Health data strategy

This report sets out LifeArc’s health data strategy, outlining how advances in data science can be harnessed to accelerate progress for people living with rare diseases.

Our Work with Patients and Communities

Patient engagement strategy

Patient engagement is essential to improving the quality and impact of health research. Our patient engagement strategy shares how we work with rare disease and global health patients and communities.

Patient and public involvement in translational research

This report brings together insights from researchers, funders and people with lived experience, outlining 10 practical actions to support meaningful involvement in translational research.

Guides and Toolkits

Impact and theory of change toolkit

This guide is designed for those working across life sciences who are developing or designing interventions, from projects and programmes to policies and strategies. It is relevant to a wide range of roles, including researchers, healthcare practitioners, commissioners, funders and programme leads.