Status: Open funding calls

Funding: Call for innovations for exceptionally low-cost monoclonal antibody (mAb) manufacturing 

In partnership with The Gates Foundation, we are requesting proposals to develop proof-of-concept for manufacturing platforms that reduce costs and enhance the production efficiency of mAbs to expand access to life-saving treatments.

Close up of scientists hands with gloves on pipetting

About the call

Monoclonal antibodies (mAbs) are one of the most powerful tools in modern medicine, offering a highly specific and effective treatment for a range of conditions – from infectious diseases to chronic illnesses.   

These biologic therapies can provide life-saving targeted interventions and improve the quality- of-life for millions of patients globally. Yet, the high production costs associated with mAbs limit access to these vital treatments for patients in low- and middle-income settings. 

mAb costs have decreased significantly in the last 30 years but have plateaued at ~ $50100 per gram. To make these life-saving treatments accessible in low- and middle-income countries, we must achieve a breakthrough: reducing the final drug substance cost-of-goods to $10 per gram.  

We are calling on innovators, scientists, engineers, and entrepreneurs- from seasoned experts in biologics to pioneers in related fields- to join us in our ambition to develop manufacturing platforms that produce monoclonal antibodies at a final drug substance cost-of-goods of $10 per gram.  

This is more than a technical challenge; it is a chance to transform millions of lives across the globe. We invite you to bring your expertise, creativity, and passion to this cause. Let’s work together to shape a future where the best medical treatments are available to everyone, everywhere. 

Apply now

Funding is currently available

For more information about this fund, click here 

Available funding

In partnership with The Gates Foundation, we will consider several proposals for awards of up to $750,000 USD for each project, with a grant term of up to 18 months.  

Each organisation will make coordinated but independent award decisions. Application budgets should be commensurate with the scope of work proposed. 

Application eligibility

The primary outputs of this challenge will be: 

  • development of a conceptual facility design.
  • generation of bench or lab-scale process data with sufficient analytical data to demonstrate the ability to produce an antibody at a final drug substance cost-of-goods of $10 per gram that could meet requirements for human applications and would support a rigorous cost-of-goods assessment by a third-party organisation (chosen by The Gates Foundation).  

A full physical demonstration that the manufacturing platform meets specific manufacturing cost targets is not required at this stage. If the success criteria from this process are met and if additional funding is available, applicants may be eligible for further support in a follow-on phase of work. 

Timeline    

This funding call opened on 18 November 2024 and will close 31 January 2025 at 11:30am Pacific Time.  

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