What the technology does

SiR (Self-inactivating rabies vector) can deliver genome editing machinery to either a defined neural networks or the whole CNS.

Advantage

Pan-CNS infectivity of the vector, through polysynaptic movement, allows for disorders affecting the whole CNS to be treated through genome editing. Alternatively monosynaptic movement can limit vector distribution and genome editing to a defined area.

Main application field

CNS disorders

Modality

Genome engineering

Status

Technology ready for evaluation and licencing

Intellectual Property

Patent application filed May 2017 (GB1706945.1)

Offering

Exclusive or non-exclusive licence

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