What the technology does
SiR (Self-inactivating rabies vector) can deliver genome editing machinery to either a defined neural networks or the whole CNS.
Pan-CNS infectivity of the vector, through polysynaptic movement, allows for disorders affecting the whole CNS to be treated through genome editing. Alternatively monosynaptic movement can limit vector distribution and genome editing to a defined area.
Main application field
Technology ready for evaluation and licencing
Patent application filed May 2017 (GB1706945.1)
Exclusive or non-exclusive licence