Transgenic mouse model of human tauopathy.

The line expresses human 0N4R Tau with a P301S mutation under the control of the murine Thy1 promoter. The P301S mutation causes a dominantly inherited tauopathy in humans. The transgenic mouse model recapitulates many hallmarks of tauopathy, including tau hyperphosphorylation, tau filament formation and neurodegeneration in brain and spinal cord.

Strain name

Thy1-hTau.P301S

Genetic Background

CBA x C57BL6

Key original publication

Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51. PubMed.

 

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