hTau: p301s mouse model

Track code: A857/3004

Species: Mouse

Background: CBA x C57BL6

Modification Type: Knock-in – Thy1 promoter

Modification: Expresses human 0N4R Tau-P301S

Disease Modelled: Neurodegeneration

Strain Designation: N/A

Description:

The P301S mutation causes a dominantly inherited tauopathy in humans. The transgenic mouse model recapitulates many hallmarks of tauopathy, including tau hyperphosphorylation, tau filament formation and neurodegeneration in brain and spinal cord.

Name(Required)

First Last

Organisation

Role

Email(Required)

Enter Email Confirm Email

Phone number

Comments(Required)

Please let us know what's on your mind. Have a question for us? Ask away.

In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. If you would like your data to be removed, please email info@lifearc.org.

Please see our Privacy Policy in relation to the personal data you submit to us through this page.