Therapeutic area
Background info
Intellectual property

Transgenic mouse model of human tauopathy.

The line expresses human 0N4R Tau with a P301S mutation under the control of the murine Thy1 promoter. The P301S mutation causes a dominantly inherited tauopathy in humans. The transgenic mouse model recapitulates many hallmarks of tauopathy, including tau hyperphosphorylation, tau filament formation and neurodegeneration in brain and spinal cord.

Strain name


Genetic Background

CBA x C57BL6

Key original publication

Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51. PubMed.



Please get in touch with the LifeArc Technology Transfer Team by filling out the form below:

  • Hidden
  • In submitting your personal data via this form, you consent to being contacted via the details provided so that your enquiry can be responded to. A backup of your data will be held but only authorised individuals will be able to access your data. If you would like your data to be removed, please email
    Please see our Privacy policy in relation to the personal data you submit to us through this page.
All Licensing Opportunities