Posted:

Scientist, Biophysical Characterisation – 12 month contract

Stevenage
Biologics, Discovery & Development
ref: 371
Full time

Closing Date:

24 June 2024

`Job Title: Scientist, Biophysical Characterisation – 12 month contract 
Location: Stevenage 
Job Type: 12 month contract 


Agencies: We will only work with recruitment partners on our preferred supplier list and will not engage with speculative CVs submitted.

Are you passionate about making life science life changing and delivering impact for patients? We want to hear from you. 


About the role:

The Biologics Discovery and Development group is focused on the delivery of high-quality therapeutics, using a single B-cell platform for antibody discovery, as well as humanising non-human antibodies. This role sits within our Analytical Sciences team, and as a Scientist you will use your expertise to develop and run our developability and other biophysical analysis platforms to progress our projects. You will be encouraged to contribute at multiple stages of the projects, with opportunities to apply and expand your skillset across our Analytical Sciences team and our Translational Therapeutic Platforms.

We are looking for an experienced and a passionate Biophysical Scientist with an interest in characterising antibodies and other proteins for the benefit of patient healthcare. This is an opportunity for a knowledgeable and enthusiastic person to join the Biologics Discovery and Development team within LifeArc’s Translational Therapeutic Platforms. You will support LifeArc’s drug discovery programmes by the initial characterisation and in depth developability and biophysical assessment of monoclonal antibodies, as well as characterising other proteins. A Scientist is a professional who can perform specialised and non-routine experiments and demonstrate an understanding of the scientific rationale of their assigned project(s). They work independently to conduct research and experiments for assigned areas for each project, analyse, and interpret the data and present results/conclusions to line manager/project leaders and wider project team).


Role responsibilities:

  • Support the production of new antibody therapies, target antigens, and other proteins by performing characterisation (including CE SDS and SEC MALS), analysing and interpreting the data, and communicating the results.
  • Address specific analytical questions using a wide range of analytical techniques including cIEF, DLS/thermal melt, SEC MALS, CIC, and HIC, analysing the data, and communicating results to the end user or project team.
  • Develop new analytical methods and data analyses to increase our capabilities and address specific research questions that will contribute to the development of new therapeutics. 

 

About you:

  • Demonstrated strong experimental planning and data analysis and interpretation skills, as well as an aptitude for picking up new concepts quickly.
  • Excellent oral and written communication skills.
  • An ability to communicate across scientific disciplines and to small and large teams.
  • An ability to prioritise tasks effectively while under pressure.
  • Willingness to embrace opportunities to expand skills with new methods or equipment.
  • Has intellectual curiosity, as well as critical and analytical thinking skills.
  • Takes an organised, meticulous, detail focused, and accurate approach to their work.
  • Works well with others, accurately follows directions, is self-motivated, and adaptable.
  • An ability to prioritise tasks effectively while under pressure. 
  • Act as a role model, bringing our principles to life.

 
Education & experience required: 

  • PhD in a relevant discipline/field OR BSc/MSc Degree with relevant laboratory experience in an industrial or academic setting.
  • Experience of characterizing proteins biophysically in an academic or industrial setting.
  • Experience with some analytical protein techniques such as cIEF, DLS/thermal melt, SEC MALS or analytical SEC, CIC, HIC, IEX, and glycan analysis.

Desirable 

  • Experience in mass spec characterization of antibodies or other proteins.
  • Experience of antibody discovery approaches, especially practical experience within a translational or drug discovery setting
  • Experience with high throughput methodologies and analysis of large data sets with associated data capture, handling, and interpretation.
  • Good understanding of antibody sequence and structure

 

About us:

At LifeArc, our ambition is to make life science life changing. We do this by advancing scientific discoveries beyond the lab, faster, so that they can shape the next generation of diagnostics, treatments, and cures. 

Working at the cutting edge of translational science and as the early-stage translation specialists, we progress scientific discoveries on their journey to becoming a medicine, diagnostic or intervention that can improve patients’ lives. Our work begins by seeking out innovative science, then helping to develop this to a point where there is a clinical and commercial pathway for others to invest the time and money to take it further forward. 


What we can offer you:

Focused on finding life changing solutions for underserved patients, our people thrive in an inclusive, and supportive environment that prioritises their health and wellbeing. Our multidisciplinary approach guarantees our people growth opportunities, while our culture of innovation and collaboration drives the impact we make delivering on our purpose of ‘putting patients at the centre of everything we do’. 

We are dedicated to creating a diverse, flexible, equitable and happy work environment so our colleagues can thrive as their truest selves. We act with courage, curiosity, care & commitment to deliver quality & excellence for our patients and each other Join us, and you’ll be given the scope to develop your professional skills and experience in a safe, supportive and challenging environment

Salary will be determined by qualifications and experience along with other exceptional benefits. Because we understand everyone has different requirements, our flexible benefits allow you to choose those which are important to you. Our pension scheme offers employer contributions of up to 12%, private health insurance, and annual leave of 31 days PLUS bank holidays. 

Don’t meet every single requirement? Studies have shown that women and people from minority ethnic backgrounds, for example, are less likely to apply to jobs unless they meet every single qualification. At LifeArc we are dedicated to building a diverse, inclusive, and authentic workplace, so whatever your background or lived experience, if you’re excited about this role but your experience doesn’t align perfectly with every qualification in the job description, we encourage you to apply anyway. Our top priority is finding the best candidate, and you may be just right for this or other roles. 

We all have potential. At LifeArc, you’ll discover what you can really do with it.


 

 


Equal Opportunities

We are an equal opportunity employer. Find our more information about opportunities for all at LifeArc here. We only work with preferred recruitment suppliers and will not engage with speculative CVs supplied. Note that the closing date may be brought forward if we find the right person for this role

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