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LifeArc, we want to hear from people who are as passionate as we are about making life science life changing that can improve patients’ lives. 

A bit about the role: 

LifeArc have a fantastic opportunity for a Principal Scientist to lead a team of scientists supporting our Translational Therapeutic Platform group. You will have expertise in biologics drug discovery processes with a focus on upstream and downstream processes of antigens and biologics production and expertise with biophysical characterisation to identify the optimal pre-clinical candidates for further development.  


The role involves working as part of a multi-disciplinary team and interacting with colleagues across multiple functions and platform groups. There is also the scope to lead the scientific rationale of one or more projects or lead across multiple projects in a specialised scientific field or platform development. 

About you: 
Education & experience required 

Education & experience:  

  • A track record of leading teams (up to 5-10 people) as an experienced line manager  

  • Significant experience of working on projects related to biologics drug discovery and/or development. 

  • Experience coaching and mentoring others. 

  • Experience in technical leadership of multidisciplinary projects through to delivery 

  • Theoretical and practical scientific knowledge and expertise/experience typical of a Masters Degree or PhD or substantial practical work experience in a relevant discipline. 

  • A track record of leading projects or large components of projects that demonstrate ability to deliver according to project plans and the creation of novel solutions to complex problems. 


Skills & abilities: 

  • Substantial depth of the drug parameters that matter for successful drug development. 

  • Expertise in Protein Sciences including Developability assessment of monoclonal antibodies and other modalities. 

  • Structural Biology and Molecular Modelling experience   

  • In-depth knowledge and understanding of protein expression systems and relevant purification strategies  

  • Experience of other biologic modalities including generation of bi-specifics, domain antibodies and antibody-based fusion proteins would be advantageous. 

  • A track record of scientific achievement within a drug discovery environment ideally across different modalities  

  • Experience of delivering pre-clinical candidates and the data packages to enable partnering would be desirable. 

  • Comfortable with ambiguity and resilience in the face of unfavourable outcomes. 

  • Attention to detail. 

  • Intellectual curiosity and ability to apply knowledge/experience to work within areas outside of owns immediate expertise. 

  • Critical and analytical thinker, strong problem solver. 

  • Organised and meticulous. 

  • Detail orientated and accurate 

  • Ability to work well with others. 

  • Ability to accurately follow directions. 

  • Excellent communicator – both verbal and written. 

  • Ability to influence and persuade others. 

About us: 

At LifeArc, our ambition is to make life science life changing. We do this by advancing scientific discoveries beyond the lab, faster, so that they can shape the next generation of diagnostics, treatments, and cures. 

Working at the cutting edge of translational science and as the early-stage translation specialists, we progress scientific discoveries on their journey to becoming a medicine, diagnostic or intervention that can improve patients’ lives. Our work begins by seeking out innovative science, then helping to develop this to a point where there is a clinical and commercial pathway for others to invest the time and money to take it further forward. 

What we can offer you: 

Salary will be determined by qualifications and experience along with other exceptional benefits. Because we understand everyone has different requirements, our flexible benefits allow you to choose those which are important to you. Our pension scheme offers employer contributions of up to 12%, private health insurance, and annual leave of 31 days PLUS bank holidays. 

Join us, and you’ll have the scope to be creative and take measured risks. You’ll be rewarded for your curiosity, for working as one team, and for learning fast. And you’ll have everything you need to be your best every day. 

Don’t meet every single requirement? Studies have shown that women and people from minority ethnic backgrounds, for example, are less likely to apply to jobs unless they meet every single qualification. At LifeArc we are dedicated in building a diverse, inclusive, and authentic workplace, so whatever your background or lived experience, if you’re excited about this role but your experience doesn’t align perfectly with every qualification in the job description, we encourage you to apply anyway. Our top priority is finding the best candidate and you may be just the right candidate for this or other roles.  

We all have potential. At LifeArcyou’ll discover what you can really do with it. 


Apply now - and start translating your potential!

Please note we are actively recruiting, and the closing date may be brought forward if we find the right person for this role.

LifeArc is committed to the principles and practices of equal opportunities and to encouraging the establishment of a diverse workforce. It is our policy to employ individuals on the basis of their suitability for the work to be performed and their potential for development, regardless of age, sex, race, colour, nationality, ethnic or national origin, disability, marital status, pregnancy or maternity, sexual orientation, gender reassignment, religion, or belief. This includes creating a culture that fully reflects our commitment to equal opportunities for all.