London, Stevenage or Edinburgh
Full time
Translational Matrix Group

Job Title: Principal Scientist (Medicinal Chemistry Project Leader) 
Location: London, Stevenage, Edinburgh 
Job Type: Permanent 

Agencies: We will only work with recruitment partners on our preferred supplier list and will not engage with speculative CVs submitted. 


LifeArc, we want to hear from people who are as passionate as we are about making life science life changing that can improve patients’ lives. 

A bit about the role: 

Within the Translational Science Matrix Group, this role will work closely with the Chronic Respiratory Infection (CRI) Translational Challenge (TC) Leadership Team, to lead the planning, execution, and delivery of early-stage preclinical drug discovery projects. Focus is on delivering patient impact, primarily via development of novel antimicrobial treatments for people living with cystic fibrosis and bronchiectasis, including supporting the CF-AMR Syndicate Collaborative Discovery Programme which was launched earlier this year. 


The role will require the ability to build strong relationships, in a matrix environment, integrating both internal and external functions. Project teams are multidisciplinary and highly collaborative, so experience of working as part of multi-partner collaborations or alliances is valuable.     


A strong grounding in small molecule medicinal chemistry, iterative optimisation, and experience of project leadership are essential requirements for the role. 


About you: 

Education & experience: 

  • Educated to PhD or equivalent in Organic / Medicinal Chemistry. 
  • Extensive postgraduate experience postgraduate experience, preferably gained in large pharma, an SME or a CRO. 
  • Extensive experience of medicinal chemistry hit to lead and lead optimisation with a proven track record of success. 
  • Deep knowledge and understanding of ADMET, PK. 
  • Ability to analyse complex data sets and design compounds to address identified liabilities.  
  • Experience working on antimicrobial drug discovery projects would be an advantage, but not essential for the role. 
  • Track record of publications or patents that demonstrate the ability of complex problem-solving. 
  • Experience in technical leadership of multidisciplinary projects through to delivery. 


Skills & abilities: 

  • Comfortable with ambiguity and resilience in the face of unpredicted outcomes. 
  • Adaptive, innovative, and continually seeking improved solutions. 
  • Intellectual curiosity and ability to apply knowledge/experience to work within areas outside of owns immediate expertise. 
  • Critical and analytical thinker, strong problem solver with meticulous attention to detail. 
  • Ability to work well with others. 
  • Ability to accurately follow directions. 
  • Excellent communicator – both verbal and written. 
  • Ability to influence and persuade others. 
  • Focussed on delivery and comfortable with accountability. 


About us: 

At LifeArc, our ambition is to make life science life changing. We do this by advancing scientific discoveries beyond the lab, faster, so that they can shape the next generation of diagnostics, treatments, and cures. 

Working at the cutting edge of translational science and as the early-stage translation specialists, we progress scientific discoveries on their journey to becoming a medicine, diagnostic or intervention that can improve patients’ lives. Our work begins by seeking out innovative science, then helping to develop this to a point where there is a clinical and commercial pathway for others to invest the time and money to take it further forward. 

What we can offer you: 

Salary will be determined by qualifications and experience along with other exceptional benefits. Because we understand everyone has different requirements, our flexible benefits allow you to choose those which are important to you. Our pension scheme offers employer contributions of up to 12%, private health insurance, and annual leave of 31 days PLUS bank holidays. 

Join us, and you’ll have the scope to be creative and take measured risks. You’ll be rewarded for your curiosity, for working as one team, and for learning fast. And you’ll have everything you need to be your best every day. 

Don’t meet every single requirement? At LifeArc we are dedicated in building an inclusive workplace and a diverse workforce that can bring a range of skills, new ideas and innovative thinking to our work. So, whatever your background or lived experience, if you’re excited about this role, but perhaps feel you don’t meet every requirement in the job description, we encourage you to apply anyway. Our top priority is finding the best candidate and you may be just the right person for this or other roles. 

We all have potential. At LifeArcyou’ll discover what you can really do with it. 



Apply now - and start translating your potential!

At LifeArc, we commit to advancing equal opportunities and building a diverse workforce by ensuring a fair, inclusive, and accessible recruitment experience for all. We employ individuals based on their suitability for the work to be performed and their potential for development, regardless of age, sex, race, colour, nationality, ethnic or national origin, disability, marital status, pregnancy or maternity, sexual orientation, gender reassignment, religion, or belief. Our commitment to equity, diversity and inclusion includes creating a culture where everyone feels they belong, is valued for who they are and has the opportunity to translate their potential.

We want every candidate to do their very best. If you require special assistance or reasonable adjustments, please be sure to let us know in advance what will be most useful for you and/ or to discuss your needs.

We only work with recruitment partners on our preferred supplier list, and will not engage with speculative CVs submitted.

Please note we are actively recruiting, and the closing date may be brought forward if we find the right person for this role.

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